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REVIEW ARTICLE
Year : 2018  |  Volume : 1  |  Issue : 1  |  Page : 17-23

Testicular dysfunction and cancer: The current status


1 HOD, Army Hospital (R & R), New Delhi, India
2 B.Tech Biotechnology, Uttar Pradesh Technical University (UPTU), Lucknow, Uttar Pradesh, India

Correspondence Address:
Pankaj Talwar
Army Hospital (R & R), Delhi Cantt, New Delhi - 110 010
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/tofj.tofj_3_17

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Anticancer treatments have increased the survival rates in young cancer patients in the past 15 years due to early detection. These cytotoxic therapies affect spermatogenesis temporarily or permanently because of detrimental effect they have on germ cells. Chemotherapy impairs spermatogenesis depending on the additive dose of the drugs and the combination of the drugs used for the cancer treatment. Alkytlating agents such as Cyclophosphamide has the most detrimental effect on germ cells. Radiation therapy is also associated with the risk of permanent sterility. Cryopreservation of semen and testicular tissue in the postpubertal and adult males before the cancer treatment is the only nonexperimental and efficient method to preserve future male fertility. With the advancements in cryopreservation and assisted reproductive technologies, surviving cancer patients can use their frozen sperms to raise a family.


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