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Year : 2021  |  Volume : 4  |  Issue : 1  |  Page : 10-13

Oocyte activation

1 Director & Senior Consultant, SRM Institutes for Medical Sciences, Chennai, Tamil Nadu, India
2 Consultant in Reproductive Medicine, Institute of OBG & IVF, SRM Institutes for Medical Sciences, Chennai, Tamil Nadu, India

Correspondence Address:
Dr, P M Gopinath
Institute of Obstetrics, Gynecology & IVF, SRM Institutes for Medical Sciences, SIMS Hospital, No. 1, Jawaharlal Nehru Salai, Vadapalani, Chennai 600026, Tamil Nadu.
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/tofj.tofj_5_21

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Though the application of advanced assisted reproductive technologies, such as in vitro fertilization and intracytoplasmic sperm injection (ICSI), circumvents many factors resulting in infertility, it still has its challenges. Among the various reasons, total fertilization failure attributed to oocyte activation deficiency (OAD) is a recognized cause. The application of assisted oocyte activation (AOA) during ICSI has been reported to overcome this issue and improve outcomes. The objective of this review article is to provide an overview of the currently available data regarding oocyte activation, identify areas for further research, and draw conclusions. Many diagnostic methods are developed to diagnose OAD, and thus, it helps to streamline its application. Similarly, many methods of activation are studied, but there is no proposed standardization in techniques, which indicates this area of expertise needs more research for broad application. Hence, AOA cannot be universally applied, as it is not beneficial in all cases of suspected OAD, which eventually points to the need that consensus guidance in clinical practice for the use of AOA should be available to guide clinicians. Importantly, a couple should be well informed about the advantages and risks associated with AOA-ICSI before application.

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